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1P-LSD 150ug Micro Pellets

1-propionyl-lysergic acid diethylamide  Micro Pellets (150 ug) 

Relevant identified uses: For research use only, not for human or veterinary use  

NOTE: This research chemical is restricted in certain countries, region(s) and including individual states in USA.  For some guidelines and more details please review our Restricted Territories page on our website.



$35.00 per unit
Quantity*
Product Description

1P-LSD Micro Pellets (150 ug)     

1-propionyl-lysergic acid diethylamide Hemi-L-Tartrate / (6aR,9R)-N,N-Diethyl-7-methyl-4-propanoyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide Hemi-L-Tartrate

Molecular Formula: C23H29N3O2

Molecular Weight:  379.504 g·mol−1

Form: Hemi-L-tartrate

IUPAC:[3-[2-[Isopropyl(methyl)amino]ethyl]-1H-indol-4-yl] acetate

CAS: 2349358-81-0

Material Data Safety Sheet: Available upon request

NMR: Available upon request

LCMS: Available upon request

This research chemical is restricted in certain countries, region(s), and including individual states in the USA.  For some guidelines and more details please click this link:  https://chemlogix.ca/restricted-teritories 

Additional Information

Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD), October 2015, Drug Testing and Analysis, DOI, 10.1002/dta.1884.

 
Abstract:
1-Propionyl-d-lysergic acid diethylamide hemitartrate (1P-LSD) has become available as a ‘research chemical’ in the form of blotters and powdered material. This non-controlled derivative of d-lysergic acid diethylamide (LSD) has previously not been described in the published literature despite being closely related to 1-acetyl-LSD (ALD-52), which was developed in the 1950s. This study describes the characterization of 1P-LSD in comparison with LSD using various chromatographic and mass spectrometric methods, infrared and nuclear magnetic resonance spectroscopy. An important feature common to LSD and other serotonergic hallucinogens is that they produce 5-HT2A-receptor activation and induce the head-twitch response (HTR) in rats and mice. In order to assess whether 1P-LSD displays LSD-like properties and activates the 5-HT2A receptor, male C57BL/6 J mice were injected with vehicle (saline) or 1P-LSD (0.025–0.8 mg/kg, IP) and HTR assessed for 30 min using magnetometer coil recordings. It was found that 1P-LSD produced a dose-dependent increase in HTR counts, and that it had ~38% (ED50 = 349.6 nmol/kg) of the potency of LSD (ED50 = 132.8 nmol/kg). Furthermore, HTR was abolished when 1P-LSD administration followed pretreatment with the selective 5-HT2A receptor antagonist M100907 (0.1 mg/kg, SC), which was consistent with the concept that the behavioural response was mediated by activation of the 5-HT2A receptor. These results indicate that 1P-LSD produces LSD-like effects in mice, consistent with its classification as a serotonergic hallucinogen. Nevertheless, the extent to which 1P-LSD might show psychoactive effects in humans similar to LSD remains to be investigated.
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